abstract：BACKGROUND:Irinotecan plus intravenous 5-fluorouracil with leucovorin is effective against gastrointestinal cancer. S-1 is an oral fluoropyrimidine derivative combining tegafur with the modulators 5-chloro-2,4-dihydroxypyrimidine (a potent dihydropyrimidine dehydrogenase inhibitor), and potassium oxonate (an orotate ph...

journal_title：International journal of clinical oncology

authors： Yamada Y,Yasui H,Goto A,Arai T,Ura T,Hamaguchi T,Muro K,Shimada Y,Shirao K

更新日期：2003-12-01 00:00:00

abstract：:It is well known that the expression of anticancer drug-resistant factors is elevated in patients with primary refractory or relapsed chronic lymphocytic leukemia (CLL) who have been treated with chemotherapy. We report here two C(H)OP refractory patients with CLL in whom salvage chemotherapy chosen by evaluating anti...

journal_title：International journal of clinical oncology

authors： Matsunaga T,Kogawa K,Fujimi A,Takizawa K,Takahira N,Takemoto N,Tanaka I,Akiyama T,Sato T,Takayama T,Terui T,Sakamaki S,Niitsu Y

更新日期：2003-10-01 00:00:00

abstract：:Despite major improvements in the treatment of early-stage breast cancer over the past 15 years, many controversies exist surrounding the optimal adjuvant therapies for these patients. Adjuvant chemotherapy has been demonstrated to reduce recurrence and improve mortality, but questions persist as to what is the optima...

journal_title：International journal of clinical oncology

authors： Gradishar WJ,O'Regan RM

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Cancer patients are at high risk of developing a second cancer after the treatment of initial cancers. Understanding the characteristics of multiple primary cancer is important to establish an effective surveillance program for the early detection of second cancers. METHODS:We analyzed the cancer registry r...

journal_title：International journal of clinical oncology

authors： Ueno M,Muto T,Oya M,Ota H,Azekura K,Yamaguchi T

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify the role of Bcl-2 protein and adrenomedullin (AM) expression in relation to apoptosis in the neoplastic changes of squamous epithelium of the uterine cervix. METHODS:Apoptosis in sections of normal cervical epithelium, cervical intraepithelial neoplasia (CIN), and i...

journal_title：International journal of clinical oncology

authors： Li Z,Takeuchi S,Ohara N,Maruo T

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:This retrospective study was carried out to ascertain the extent of efficacy of nonsurgical salvage modalities, mainly chemotherapy (CT) alone or chemoradiotherapy (CTRT), for loco-regional failures in head and neck cancer (HNC). METHODS:Between 1991 and 1999, 131 patients with HNC, mostly stages III and IV...

journal_title：International journal of clinical oncology

authors： Datta NR,Nagar YS,Singh S,Naryan L

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Cyclin E and p27 play pivotal roles in cancer development and progression. We investigated whether the prognosis in cases of non-small cell lung cancer without lymph node metastases that underwent complete resection could be associated with tissue expression of cyclin E, p27, and Ki-67. METHODS:Tumors from ...

journal_title：International journal of clinical oncology

authors： Takahashi S,Kamata Y,Tamo W,Koyanagi M,Hatanaka R,Yamada Y,Tsushima T,Takaya S,Fukuda I

更新日期：2002-12-01 00:00:00

abstract：:Anti-aromatase agents inhibit the cytochrome p-450 component of the aromatase enzyme complex responsible for the final step of estrogen biosynthesis in peripheral tissues. These drugs can be classified into first-generation (e.g., aminoglutethimide), second-generation (e.g., formestane and fadrazole), and third-genera...

journal_title：International journal of clinical oncology

authors： Mokbel K

更新日期：2002-10-01 00:00:00

abstract：:Carboplatin has proven to be effective in the treatment of patients with recurrent ovarian cancer who have responded to platinum-based first-line chemotherapy. However, thrombocytopenia is a problem in heavily pretreated patients. Paclitaxel has a so-called platelet-sparing effect, but until now it was unknown whether...

journal_title：International journal of clinical oncology

authors： Ishikawa H,Fujiwara K,Suzuki S,Tanaka Y,Kohno I

更新日期：2002-10-01 00:00:00

abstract：:Third-generation aromatase inhibitors and inactivators have earned their place in the treatment of metastatic breast cancer. The third-generation aromatase inactivator exemestane was found to be superior to megestrol acetate as second-line endocrine therapy in postmenopausal women, with respect to time to progression ...

journal_title：International journal of clinical oncology

authors： Lønning PE

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:SmithKline Beecham synthesized camptothecin analogs and identified nogitecan hydrochloride (topotecan) with a broad spectrum of antitumor activity and less toxicity than camptothecin. Because preclinical and overseas clinical data indicated the antitumor effect of nogitecan hydrochloride with a 5-day repeat-...

journal_title：International journal of clinical oncology

authors： Kobayashi K,Hino M,Fukuoka M,Takeuchi K,Furuse K,Yoneda S,Hasegawa K,Noda K,Kinoshita H,Kimura I,Taguchi T,Kanamaru R,Horikoshi N,Niitani H

更新日期：2002-06-01 00:00:00

abstract：:A 48-year-old woman with small-cell lung cancer received combined chemotherapy consisting of cisplatin (CDDP) and etoposide (Vp-16). Although the gustatory threshold in the glossopharyngeal nerve area was normal (14 dB) before chemotherapy, it rose to 22 dB on day 8 of chemotherapy, and it could not be measured, becau...

journal_title：International journal of clinical oncology

authors： Minakata Y,Yamagata T,Nakanishi H,Nishimoto T,Nakanishi M,Mune M,Yukawa S

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:When soft-tissue sarcomas occur near neurovascular structures, preoperative images cannot always reveal the accurate relationship between the tumor and these structures. Therefore, in some patients, neurovascular structures are sacrificed unnecessarily. In other patients, neurovascular structures are preserv...

journal_title：International journal of clinical oncology

authors： Matsumoto S,Kawaguchi N,Manabe J,Matsushita Y

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:No effective follow-up strategy for non-Hodgkin's lymphoma (NHL) has been identified to date. The aim of this study was to assess the value of a strict follow-up procedure in patients with NHL after they showed clinical remission. METHODS:One hundred and twenty-one patients with localized NHL of the head an...

journal_title：International journal of clinical oncology

authors： Nakamura K,Sasaki M,Kunitake N,Kimura M,Watanabe T,Sasaki T,Terashima H,Kuwabara Y,Sakai S,Masuda K

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Lip carcinomas are rare oral tumors, and there have been few reports of lip carcinoma in Japan. METHODS:Of 914 patients with oral carcinomas treated between January 1980 and December 1998, 12 (1.3%) had lip carcinoma and 5 (0.5%) had lip mucosal carcinoma. We investigated the clinicopathological features of...

journal_title：International journal of clinical oncology

authors： Ogura I,Amagasa T,Iwaki H,Kijima T,Kurabayashi T,Yoshimasu H

更新日期：2001-06-01 00:00:00

abstract：:Pseudoaneurysm complicating osteochondroma is extremely rare. We describe a pseudoaneurysm in the popliteal fossa of a 21-year-old man, occurring 5 years after apparently incomplete resection of an osteochondroma at that site. We found magnetic resonance imaging and magnetic resonance angiography to be of great diagno...

journal_title：International journal of clinical oncology

authors： Otsuka T,Yonezawa M,Kamiyama F,Matusita Y,Matui N

更新日期：2001-04-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract. Recently, we found that GISTs expressed KIT, a receptor tyrosine kinase encoded by the protooncogene c-kit. We propose that GISTs may originate from interstitial cells of Cajal (ICCs), which are considered to ...

journal_title：International journal of clinical oncology

authors： Hirota S

更新日期：2001-02-01 00:00:00

abstract：:Specific allelic losses in the DNA of tumor cells are potential indicators of postoperative prognosis. Patients whose tumors showed allelic losses at 1p34, 3p25, 8p22, 13q12, 17p13.3, or 17q21.1 had a significantly higher risk of postoperative mortality than women whose tumors retained both alleles at those loci (the ...

journal_title：International journal of clinical oncology

authors： Hirano A,Utada Y,Haga S,Kajiwara T,Sakamoto G,Kasumi F,Nakamura Y,Emi M

更新日期：2001-02-01 00:00:00

abstract：:Background. We aimed to evaluate the clinical usefulness of measurement of the free-to-total (F/T) ratio of prostate-specific antigen (PSA) for the differentiation of prostate cancer from benign prostate hyperplasia (BPH) and for the staging of prostate cancer. Values for PSA density (PSAD) and PSAD adjusted to the tr...

journal_title：International journal of clinical oncology

authors： Furuya Y,Akakura K,Ito H

更新日期：2000-02-01 00:00:00

abstract：:A case of mantle cell lymphoma (MCL) associated with multiple lymphomatous polyposis (MLP) is reported is a 62-year-old woman, with special reference to the patient's clinical features and response to treatment. There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses...

journal_title：International journal of clinical oncology

authors： Tsujimura H,Takagi T,Tamaru J,Sakai C

更新日期：2000-02-01 00:00:00